Nature Immunology：结核菌可抑制免疫反应

作者简介：

Joyoti Basu
Professor,  Chemistry
PhD(Biochemistry):University of Calcutta (1988)

Research interest

1. Understanding proteins/enzymes of the cell wall biosynthesis and cell division machinery of mycobacteria at the structural and functional level as an approach towards developing agents for antimycobacterial chemotherapy.
2. Understanding the stress response of mycobacteria.
3. Dissecting mechanisms of mycobacterial pathogenesis.
4. Understanding how pathogenic mycobacteria regulate the innate immune response.
5. Understanding erythrocyte membrane structure and function.

Important publications

1. Pathak, S.K., Basu, S., Basu, K.K., Banerjee, A., Pathak, S., Bhattacharyya, A., Kaisho, T., Kundu, M. and Basu, J. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages (2007) Nature Immunology, 8, 610-618.
2. Basu, S., Pathak, S.K., Banerjee, A., Pathak, S., Bhattacharyya, A., Yang, Z., Talarico, S., Kundu, M. and Basu, J. Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-α (2007) J. Biol. Chem. 282, 1039-1050.
3. Datta, P., Dasgupta, A., Singh, A.K., Mukherjee, P., Kundu, M., and Basu, J. Interaction between FtsW and penicillin-binding protein (PBP)3 directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria (2006) Mol. Microbiol. 62, 1655–1673
4. Dasgupta, A., Datta, P., Kundu, M., and Basu, J. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. (2006) Microbiology, 152, 493-504
5. Pathak, S.K., Basu, S., Bhattacharyya, A., Pathak, S., Kundu, M. and Basu J. Mycobacterium tuberculosis lipoarabinomannan-mediated irak-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. (2005) J. Biol. Chem. 280, 42794-42800
6. Mandal, D., Mazumder, A., Das, P., Kundu, M. and Basu J. FAS-, caspase 8-and caspase 3-dependent signaling regulate the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes. (2005) J. Biol. Chem. 280, 39460-39467
7. Toye, A.M, Ghosh, S., Young, M.T., Jones, G.K., Sessions, R.B., Ramaugé, M., Leclerc, P., Basu J., Delaunay, J. and Tanner ,M.J.A. Protein 4.2 enhances band 3 (AE1, SLCA4) induced anion transport in Xenopus oocytes: effects of three natural protein 4.2 mutations associated with hemolytic anemia. (2005) Blood 105, 4088-4095
8. Pathak, S.K., Bhattacharyya, A., Pathak, S., Basak, C., Mandal, D., Kundu, M.and Basu, J. (2004) Toll-like receptor 2 and mitogen and stress-activated kinase 1 are effectors of Mycobacterium avium- induced cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 279, 55127-55136
9. Mycobacteria within its intracellular niche: survival of the pathogen or its host. (2004) Basu, J. Current Science 86, 103-110
10. Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase signaling and caspase 8 activation. Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M. and Basu, J. (2003) J. Biol. Chem. 278, 26517-26525.
11. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. Datta, P., Dasgupta, A., Bhakta, S., and Basu, J. (2002) J. Biol. Chem. 277, 24983-24987.
12. Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway. Maiti, D., Bhattacharyya, A., and Basu, J. (2001) J. Biol. Chem. 276, 329-333