Nature Immunology：结核菌可抑制免疫反应

Manikuntala Kundu
Professor, Chemistry
PhD(Biochemistry): University of Calcutta(1988)

Research interest

1. Dissecting host-pathogen interactions with reference to Helicobacter pylori and pathogenic mycobacteria.
2. Understanding the stress response in mycobacteria.
3. Understanding bacterial efflux pumps and their role in drug resistance.
4. Characterizing antibiotic resistance mechanisms in enteric bacteria.

Important publications

1.     Pathak, S.K., Basu, S., Basu, K.K., Banerjee, A., Pathak, S., Bhattacharyya, A., Kaisho, T., Kundu, M. and Basu, J. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages (2007) Nature Immunology, 8, 610-618.

2.     Pathak, S.K., Bhattacharyya, A., Basu, S., Banerjee, A., Basu, J., and Kundu, M. TLR4-dependent NF-kB activation and mitogen- and stress-activated proteins kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans- isomerase (HP0175)-mediated induction of IL-6 release from macrophages. (2006) J. Immunol., 177, 7950-7958

3.     Singh, A., Halder, R., Mandal, D., and Kundu, M. Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance. (2006) Antimicrob. Agents Chemother. 50, 3717-3723

4.     Basak, C., Pathak, S.K., Bhattacharyya, A., Pathak, S., Basu, J. and Kundu, M. (2005) The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a Toll-like receptor 4 and apoptosis signal-regulating kinase 1(ASK1)-dependent manner. J. Immunol., 174, 5672-5680

5.     Basak, C., Pathak, S., Bhattacharyya, A., Mandal, D., Pathak, S. and Kundu, M.(2005) NF-kB- and C/EBPb-driven interleukin-1b gene expression and PAK1-mediated caspase 1 activation play essential roles in interleukin-1b release from Helicobacter pylori lipopolysaccharide (LPS)-stimulated macrophages. J. Biol. Chem. 280, 4279-4288

6.     Pathak, S.K., Bhattacharyya, A., Pathak, S., Basak, C., Mandal, D., Kundu, M. and Basu, J. (2004) Toll-like receptor 2 and mitogen and stress-activated kinase 1 are effectors of Mycobacterium avium- induced cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 279, 55127-55136

7.     Mills, J.A., Motichka, K., Jucker, M., Wu, H.P., Uhlik, B.C., Stern, R.J., Scherman, M.S., Vissa, V.D., Pan, F., Kundu, M., Ma, Y.F. and Michael McNeil (2004) Inactivation of the Mycobacterial Rhamnosyltransferase, Which Is Needed for the Formation of the Arabinogalactan-Peptidoglycan Linker, Leads to Irreversible Loss of Viability. J. Biol. Chem., Vol. 279, Issue 42, 43540-43546

8.     Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M. and Basu, J.. (2003) Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated kinase signaling and caspase 8 activation. J. Biol. Chem. 278, 26517-26525

9.     Mandal, D., Baudin-Creuza, V., Bhattacharyya, A., Pathak, S., Delaunay, J., Kundu, M. and Basu, J. (2003) caspase 3-mediated proteolysis of the N-terminal cytoplasmic domain of the human anion erythroid exchanger (Band 3) J. Biol. Chem. 278, 52551-52558

10.  Bhattacharyya, A., Pathak, S., Datta, S., Chattopadhyay, S., Basu, J. and Kundu, M. (2002) Mitogen-activated protein B regulate Helicobacter pylori-mediated interleukin-8 releasekkinases and NF- from macrophages. Biochem. J. 368, 121-129

11.  Bhattacharyya, A., Pathak, S., Kundu, M. and Basu, J. (2002) Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-a release from macrophages. FEMS Immunology and Medical Microbiology. 34, 73-80.

12.  Baranwal, S., Dey, K., Ramamurthy, T., Nair, G.B. and Kundu, M. (2002) Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae Antimicrob. Agents Chemother. 46, 2676-2678.

13.  Saha Choudhuri, B., Bhakta, S., Barik, R., Basu, J., Kundu, M. and Chakrabarti, P. (2002) Overexpression and functional characterization of an ABC transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. Biochem. J. 367, 279-285